Woah....I just found out about this new product (Histame) that I'm going to try. Its actually not new but just recently (in March) became available in the US and Canada.
I talked alot about histamine a couple of years back and had some testing done to check blood and urine histamine levels. The "lab" that I went to to get the samples done was a total joke, the nurse was heinous and I never got the results of my bloodwork because I switched doctors.
Anyways, back then is when I realized histamine was an issue and started avoiding high histamine foods and then pretty much all "amines".
My primary symptoms are caused by histamine releases to food and chemical triggers. This has been going on since the beginning. I have not figured out any way to ease these reactions because once my bucket drains....it very quickly fills up again and then I'm overly sensitive to chemicals and everything else around me.
Last month I was reacting to everything and was completely overloaded. There are other things besides high histamine foods that cause histamine levels to rise. Glutamates can also raise histamine levels as can sulfites and other preservatives/additives.
Histamine (like any toxin) needs to be broken down and excreted.....which cant happen when the enzyme which breaks it down becomes blocked or deficient. When the liver is overloaded by toxicity the excess histamine and other toxins are not eliminated.
I notice when histamine reactions go up (usually because of foods eaten) I will then become more sensitive to perfumes, etc. Without a doubt the histamine is putting a big burden on my liver....same as when I get overly stressed and adrenaline runs high...these chemicals remain in the body much longer than they should due to my sluggish liver.
Like the problem with salicylates there hasnt been much I could do about it except avoid the foods. Tonight I came across this new product and I'm not really gonna get too excited about it because I do not know the exact reason or metabolic issue that is responsible for the histamine intolerance in my situation. I also dont know how well this product actually works.
If a part of my problem is lack of enzyme function (a very probable scenario) then this may do some good in reducing food reactions and in turn would take a big burden off of my liver. I'm not holding my breath but I'm definately gonna try it out.
It does have fillers/binders which I probably wont tolerate but if the reason that I react to these things has to do with an inability to break down histamine....then the product should help.
Unlike Ketotefin or other antihistamines...(even natural ones like vitamin C)....Histame doesnt just block the histamine....it replaces the enzyme that may be deficient (for whatever reason). Something like this, together with ketotefin may actually bring some relief since most of my histamine reactions are coming from foods eaten.
In my case these are not IgE allergies (Histame wont work for true allergy) and they are not IgG mediated food intolerances either. So if the immune system isnt producing antibodies which are causing these reactions that can only mean that some enzyme is not functioning properly and chemicals are accumulating which under normal circumstances would not be happening. Thats why I focused on amines and salicylates a long time ago...because no antibody reactions are occuring (according to my tests)....and reactions are not consistent....and vary greatly from one day to the next.
Heres some info about histamine....there is also more info. in the OMG thread if anyone is interested.
Not all food intolerance involves IgG-antibodies. Many food products contain histamine in large amounts, and if the body cannot break down this histamine sufficiently, it crosses the intestinal wall and enters the blood stream. Here it can cause symptoms which are comparable to allergy. This is because histamine acts as a hormone, and is responsible for the allergy symptoms associated with “true allergy.” In allergic reactions, histamine is given off by certain white blood cells, which overreact to the presence of certain harmless substances in the bloodstream.
The body normally produces an enzyme called diaminoxidase (DAO), which breaks down histamine. If the production of this enzyme is, for one reason or another, insufficient, the intake of histamine containing food and drink can cause an increased histamine level in the blood, which causes allergy-like symptoms. Foods which contain histamine can also cause symptoms if they contain substances which cause the body’s white blood cells to release histamine.
Many medicines inhibit DAO, and therefore lead to histamine build up in the body. This is also true of alcohol, which both increases the intestine’s histamine absorption and inhibits its breakdown. Alcohol together with histamine rich food therefore causes worsened symptoms. Histamine in food is not broken down by cooking or freezing.
Examples of food and drink with high histamine content: Red wine, champagne cheese, yeast / baking powder, salami, fish (especially conserves), spinach, and sauerkraut. A rule of thumb is that the older, more mature, or more prepared food is, the higher the histamine content. For example, fresh fish contains very little histamine. The content of histamine in red wine can also vary greatly; some wines cause symptoms while others do not. Symptoms from red wine are due to its tyramine content.
Examples of food with little histamine, but with the ability of stimulating the body’s release of histamine: Cocoa / chocolate, tomatoes, strawberries, citrus fruits, pineapple, kiwi, mango, buckwheat, crabs and shellfish, nuts, sunflower seeds, vinegar, and mustard.
Examples of additives which can stimulate the white blood cells to release histamine: Glutamate (E620-623), benzoate (E210-213), sulphites (E220-228), nitrates (249-252), as well as some food colourings.
The symptoms of histamine intolerance can be: Stomach pain, diarrhoea or constipation, intestinal gas, headache / migraine, runny nose, itchy eyes, various rashes, itchiness, tiredness, nausea, dizziness, concentration problems, and low blood pressure. They can start after a few minutes or after a few hours and there can come in varying degrees. Their frequency and severity varies from day to day, from person to person.
I have all of these symptoms (except stomach pain and dizziness) but most dont bother me....its mostly the headache/migraine/swelling and skin irritations which include burning more than itching. The low blood pressure sucks too because I think thats what brings on my drop in body temp. and chills after eating. Bad reactions cause concentration problems.
I also think the flushes I get may be due to excess histamine...which is why I experienced alot of that last month when I was reacting to everything.
My reactions vary depending on the food or chemical involved. Some will cause migraine but no kind of noticeable skin stuff. Free glutamates in processed foods cause welts on my face...not alot....just one or two at a time and they only last a day or two as long as I dont continue to eat the food. Sulfites will cause some skin stuff too. I dont know about the rest but I can pretty much expect some mild skin stuff whenever I eat processed foods. It doesnt bother me like the swelling/headache/pressure does.
This is the link to the Histame...
I dont think it will work miracles but hopefully it does *something*.
I found out about it here...
and this link tells a little about the DAO enzyme.
If I can somehow slow down all of these reactions to stuff I eat I think my life would be pretty normal because I dont have any other disabling symptoms. Some days I feel almost completely normal and the next day I can have pain/swelling, chemical sensitivities, etc.....and its all having to do with what I ate.
I havent read anything about histamine and proteinuria. I actually have never heard of proteinuria so will have to look that one up.
I think my health would have been ok if not for the dental work. I cant say for sure but up until then I had no sensitivities at all. I had never been sensitive to any foods or chemicals. I had never experienced headaches or any type of chronic pain. Sickness or health problems was just not something that I'd ever really gave much thought to because I considered myself to be very healthy.
I think genetic susceptibility is always a factor in chronic illness but not by itself. If not for the environmental exposures and other factors that come into play...we can get by without getting sick. So, for me I would say that my diet, lifestyle, stress, exposure to pathogens and heavy metals played upon the genetic weaknesses that I was born with.
This happens more frequently nowadays as we are all exposed to more chemicals and environmental toxins than ever before. Autism would be an example. The genetic weaknesses are certainly there (in every kid).....but they have always been there even when Autism was unheard of.
I will definately see about getting tested for mastocytosis but I do believe that the histamine is more related to methylation status and possibly enzyme dysfunction due to damage in the gut or genetic weakness. The DAO enzyme which breaks down histamine in the intestine is not something that I ever had tested since all of genetic testing I've done was with regards to the liver and detoxification.
Heavy metals block enzymes....mercury can block any enzyme system in the body...which is why when we already have slower functioning enzymes (due to our genetic make-up) the heavy metals can come into the picture and create a situation where systems that were once a little slower functioning then become significantly impaired. That would be more of an aquired enzyme deficiency even if there was already a "weakness" there to begin with.
An example is the enzyme which is responsible for the breakdown of gluten and casein....DPPIV. This enzyme is known to be very sensitive to mercury and is easily blocked/inhibited by mercury. Then you end up with symptoms of gluten and casein intolerance which would never have been an issue without that exposure.
From what I have read studies have shown that a very high percentage (forgot the exact number) of those who have high histamine in blood have low DAO activity....so the ability to degrade histamine is usually impaired.
Besides that, everything else I've read pretty much points to methylation status. There is alot of talk regarding high histamine levels on the Autism boards where methylation is discussed. So high histamine definately can be related to impaired methylation. Impaired methylation is already confirmed for me with testing that I've had done and it is also a factor in all cases of Autism.
I do think that the mast cells are triggered by alot of things which wouldnt occur if the body were able to detoxify efficiently. So I think there is likely a combination of increased histamine release due to lots of toxins, etc circulating in the blood stream...as well as an impaired ability to degrade the histamine and get rid of it.
I definately feel that folic acid makes things worse for me. I take a handful of B vitamins and have no problems with them but I had major problems in the past with any B-complex which included folic acid. I have problems when I try to take folic acid by itself. So far I have not ever been able to take it for more than 1 or 2 days before I get noticeably worse.
I have not seen any similar health problems occuring in my family but then I'm not familiar with relatives on my dads side. His family is quite large but I am not in contact with my relatives on that side of my family. I do know that addiction runs high on that side of my family. My dad has been addicted to drugs and alcohol his whole life and his father was also alcoholic. I was addicted to cigarettes....but never drugs or alcohol. I had the problems with OCD along with symptoms of hyperactivity but had always attributed it to hyperthyroidism but I do recall having those whooshing/pulse sounds in my head at night even back then.
These are more symptoms of high histamine but I think in most cases not all of these symptoms are present. I will mark any symptoms that I have or have had with an *
Signs, symptoms & indicators of Histadelia
* Excess mucous: Histamine can cause additional mucus
Good tolerance of cold
Poor tolerance of heat
* Unexplained nausea
* Poor pain tolerance
* Excess/abundant saliva in mouth
* Hyperactivity: Histamine speeds up metabolism producing a
tendency towards hyperactivity.
* Being highly motivated: Those with elevated histamine
(histadelics) tend to work compulsively.
* A hard-driving personality: Histadelics tend to work
* Good creativity/imagination: Histadelics are often
* Strong sexual desire
* Joint pain/swelling/stiffness
* Excess perspiration
* Warm skin
Conditions that suggest Histadelia (Histamine High):
Allergy: Allergic Rhinitis / Hay Fever
* Depression: Histadelics are often chronically and
suicidally depressed. (This was only when I was very sick)
* Obsessive-Compulsive Disorder (OCD): Histadelics are often
prone to obsessions, compulsions, and addictions.
* Addictions / Addictive Tendencies: Nutritional treatment
for drug and alcohol users will depend on the results of a
test for blood histamine levels. In one series of such
analysis, all users proved to have high histamine levels,
leading the scientist to conclude that this abnormality -
with its impact on brain function - is a major force in
creating addiction. [Nutrition Guide for the Prevention
and Cure of Common Ailments and Diseases, Carlton
Fredericks, PhD. p.58]
* Insomnia: The overarousal seen in histadelia may
contribute to insomnia.
* Muscle Pains (Myalgia)
* History of unexplained nausea
Slender fingers / toes: Histadelics often have long
fingers and toes.
Unfortunately I cant post any links because nothing can be seen unless you're a member of that forum.
"I gave a talk in October 2006 in Boston, entitled Stress and Aggression where I spent quite a bit of time covering the histamine connection.
In terms of histamine, the use of SAMe can often be helpful.
Based on his AHCY status, I would check methionine levels on his urine amino acid test. I find that once we do get methionine in better balance for those with AHCY that some of the histamine issues tend to decrease.
I did not suggest the Folapro as I would like to get the rest of his system in balance first, since that seemed to trigger some of these behaviors."
" I have worked with children who were both COMT - - as well as COMT + + with high histamine. High histamine suggests to me that the methylation pathway is not supported as well as it needs to be."
This quote is from another Dr. (not Yasko):
"Effective "markers" for methylation are (1) whole blood histamine, available from Quest and LabCorp; (2) Absolute Basophils, available from Direct Healthcare, Inc in the Chicago area.
Elevated histamine and/or elevated basophils indicate undermethylation. Review of symptoms and medical history can bolster the diagnosis. For example, most undermethylated persons exhibit seasonal allergies,
perfectionism, strong wills, slenderness, OCD tendencies, high libido, etc.
The SAM cycle in which dietary methionine is converted to SAMe (the primary methylation donor in the body), and then to homocysteine, is a dominant cascade of reactions in methylation and also is very important in production of glutathione, cysteine, and other aspects of sulfur chemistry.
Most persons with depression, oppositional defiant disorder, OCD, bipolar disorder, or schizophrenia exhibit a genetic abnormality in methylation..... which appears to be central to their illness."
"Optimal methylation is needed to break down histamine involved in allergic reactions."
"First realize that there is a relationship between histamine and the methylation cycle. It ties together at FIGLU as well as carnosine and anserine to the formation of histidine which can convert to histamine. The use of SAMe for those that will tolerate it can really help with allergies. Since detox can increase in the summer due to increased levels of vitamin D (effect on dopamine) as well as increased BH4, you may want to consider some extra SAMe or methyl donors in the summer months."
"Quercetin helps to prevent the degranulation of mast cells. The mast cells are the ones that are like water balloons, filled with histamine. Also butterbur (in Petadolex) helps with this area too. "
"There is an inverse relationship between histamine and methylation in many cases. Once we get the methylation cycle under control he should have less allergy issues."
The reason I'm thinking its more related to impaired methylation is because the situation has actually improved with avoidance of high histamine foods and other things that trigger the release of histamine. At one time (about 4 years ago) I was so overloaded that I was reacting to everything....including dust, my pets, cigarette smoke from like a mile away, the heater in the house and car, car exhaust, and on and on. My head was just full of pressure and my nose was affected by everything. I think my histamine levels were probably through the roof at that time.
By focusing on reducing the load of toxic exposures (so less things are circulating my system) the histamine levels must have went down because I am not that affected anymore. Most things that were bothering me at that time are not even an issue now.
Now it is mostly foods that are still an issue....and this might be due to a combination of low DAO and impaired methylation. I would like to have blood histamine levels tested before trying methionine or SAMe to see what changes (if any) occur. My histamine levels may also be increased due to gut infections (I have fungal issues)and with impaired methylation it would be more of an issue. There would be more of a build-up....not just of histamine but toxicity in general.
I think with mastocytosis the situation would not improve so dramatically because the mast cells would continue to take over since it is a progressive condition. Without taking any type of antihistamine I dont know that it would have been possible for me to experience so much relief from the histamine overload by simply reducing the load of toxicity in my body.
The toxic burden is still high....very high....but not as bad as it once was and I still have not yet begun to support the methylation cycle.....which I believe is crucial.
I do like to have testing done of all kinds...and I've had a ton of stuff done since all this began....so I'm definately going to see about the mastocytosis. I think the more testing the better so I really dont dismiss anything that could be a possibility for me. Thanks for bringing it to my attention and I'll let you know when I get my appt. set up. :)